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A breathtaking scientific revolution is taking place – biotechnology has been progressing at stunning speed, giving us the tools to eventually gain control over biology. On the one hand solving the deadliest diseases while also creating viruses more dangerous than nuclear bombs, able to devastate humanity.
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Content
0.39 -> A breathtaking scientific revolution is taking
place – biotechnology has been progressing
6.08 -> at stunning speed, giving us the tools to
eventually gain control over biology.
11.444 -> On the one hand solving the deadliest diseases
while also creating viruses more dangerous
17.1 -> than nuclear bombs, able to devastate humanity.
21.017 -> What is going on?
25.777 -> Biotechnology is increasingly everywhere.
28.57 -> The cotton in your clothes, the vegetables
you eat, your dog.
32.84 -> Humans manipulate living things.
35.25 -> We use bacteria to produce insulin, connect
prosthetics directly with our brains and make
39.85 -> industrial enzymes to produce paper.
43.131 -> Gene therapy creates cures to previously untreatable
diseases while we are working on food crops
48.59 -> resistant to climate change.
51.01 -> Our mastery over biology has been speeding
up so much that within weeks of the first
56.104 -> Covid 19 case, the unknown coronavirus was
broken down in laboratories and analysed.
61.574 -> Scientists generated a copy of its genetic
material to create a vaccine that was ready
65.94 -> for testing months after the pandemic began.
69.214 -> Something unthinkable a decade ago.
72.96 -> Where is all this sudden progress coming from?
75.75 -> Well, it's complicated.
77.9 -> But in a nutshell: really expensive things
got cheap and knowledge of how to do
82.445 -> impressive things spread freely.
85.212 -> The Human Genome Project starting in 1990
was the first major attempt to read human
90.299 -> DNA in its entirety. 13 years and $3 billion
later, it was complete.
96.335 -> By then the cost of decoding a human genome
had fallen to about $100 million.
101.729 -> Today it is 100,000 times cheaper, costing
only about $1000.
106.875 -> How is that possible?
108.75 -> Converting DNA into computer data and then
studying it used to be a super tedious process,
114.52 -> taking expert humans around 3 years of manual
work.
118.619 -> Today it takes about two weeks and is almost
completely automated.
123.34 -> Biotechnology has gone from something restricted
to the best and well-funded laboratories staffed
128.05 -> by the world's top experts, to something affordable
enough for hundreds of thousands of people
132.66 -> to casually work on.
134.55 -> What has sped up the process even more is
that information in the field is shared
138 -> widely and freely.
139.853 -> Cutting-edge discoveries now take just about
a year to be copied in laboratories around the world,
144.216 -> a few years for anyone with a biology
background to work out, and a bit over a decade
148.58 -> for high school students to experiment with
them in schools.
151.974 -> Imagine that your local computer repair shop
could build a pristine Iphone 11 with just
156.128 -> the parts lying around, and that teenagers
are asked to build a new Iphone 5 for homework.
161.519 -> Not a crappy homemade version, the real thing.
164.55 -> This is what is going on right now in biotechnology
– a true revolution.
169.319 -> We are adding knowledge at unprecedented rates,
while things get ever faster and cheaper to do.
175.023 -> This speed means we can expect even more wonderful
things for humanity.
179.525 -> Lifesaving treatments, miracle crops and solutions
to problems we can’t even imagine right now.
185.698 -> But unfortunately progress cuts both ways.
189.059 -> What can be used for good, can also be used
for bad, by accident or on purpose.
198.573 -> For all the good biotech will do for us, in
the near future it also could easily kill
203.06 -> many millions of people, in the worst case
hundreds of millions.
207 -> Worse than any nuclear bomb.
209.034 -> The world just witnessed how fast the novel
coronavirus spread.
213.26 -> We still do not know for sure if it came from
nature or was the result of an accidental leak
217.11 -> from a lab working with corona viruses,
that’s still subject to scientific debate.
222.31 -> In the end at least 7 million people died.
225.489 -> And this was still a relatively mild virus
that didn’t cause serious disease in most of those infected.
231.128 -> But that might change in the future.
233.689 -> Wherever the last pandemic came from, the
next one might very well be our own fault
237.939 -> – in a sense, many things going on in biotechnology
could lead to this.
242.75 -> Most of all how easy it is to work with dangerous
viruses.
246.443 -> Thousands of scientists can simply order the
genetic data of infectious virus samples online
251.39 -> to experiment with them.
252.909 -> Assembling these into an artificial virus
in 2023 costs about as much as a new car,
258.19 -> including all the lab equipment.
259.889 -> At the same time, other scientists are trying
to find viruses that hide in nature,
265.023 -> like in wild bats or monkeys.
266.792 -> There are probably plenty of potentially deadly
pandemics out there.
270.823 -> Virus hunters take samples back to the lab
to learn whether the newly discovered viruses
274.94 -> are likely to spread in humans and catalogue
the danger.
278.66 -> When a biologist discovers a new virus, they
usually publish its genetic data to the public.
283.58 -> Journals are eager to share descriptions of
potentially dangerous viruses.
288.33 -> Other labs go further and make viruses more
dangerous.
292.47 -> They combine and mutate different viruses
to understand which mutations make them more
296.889 -> likely to spread between humans or make them
deadlier than their original forms.
301.02 -> And again, these results are shared freely.
304.27 -> All while synthetic DNA and equipment to rebuild
these viruses are sold online to anyone
309 -> without any or very little tracking.
311.86 -> As the tools of biotechnology get ever cheaper
and easy to use and the data on
316.327 -> dangerous viruses keeps multiplying, it is only a matter
of time before a well-meaning scientist shares
321.47 -> blueprints for the equivalent nuclear bomb
of viruses, a superbug that will cause millions of deaths
326.902 -> – and someone uses it.
328.952 -> Maybe because they have bad intentions, maybe
because they are irresponsible or sloppy.
333.11 -> We are creating an environment in which it
is increasingly easy for anyone to create
337.34 -> a weaponized virus in their backyard.
339.66 -> This is scary.
341.71 -> The world would be plunged into an unending
crisis as new pandemics pop up year after year
346.831 -> or all at once – killing large parts
of the world’s population, doing unimaginable
351.19 -> damage to civilisation as a whole, and possibly
undoing centuries of progress.
360.274 -> It’s not the first time we’ve faced a
challenge like this and we are not helpless
364.586 -> – think of nuclear technology.
366.46 -> Something extremely powerful and dangerous
with huge upsides and downsides.
371.424 -> Nuclear energy was born from weapon programs,
so its creators were always aware of the potential
376.273 -> for their knowledge to be abused.
378.23 -> From the very beginning it was clear that
knowledge in this field and access to the
381.58 -> technology needed to be handled with utmost
care.
384.729 -> So a lot of effort has gone into making sure
no radioactive material disappears from sight
389.449 -> or that countries don’t try to hide weapons
development behind energy programs.
393.81 -> The result hasn’t been perfect, but considering
the 411 nuclear power stations running today,
399.19 -> we’ve been very successful.
401.134 -> Likewise, no researcher would think to share
data on how to turn common laboratory equipment
405.599 -> into bomb-making machines on the internet.
407.8 -> There is no reason we could not handle the
really dangerous aspects of biotechnology
412.19 -> in a similar way!
414 -> Experts have come up with three sort of bullet
points:
417.573 -> First we need to delay the next deadly pandemic
by getting a grip on how we treat dangerous viruses.
423.519 -> Their genetic data should be treated as an
infohazard: information that poses a danger
428.65 -> to society if it is shared without care.
431.56 -> In other words, not just anyone should be
able to order dangerous DNA online.
435.61 -> And if you do, you should be tracked, so it
becomes much harder for the wrong people
439.506 -> to access the really spicy stuff.
442.23 -> The next step is detecting the danger by becoming
aware which viruses are present among us
447.242 -> and are spreading explosively between humans.
450.418 -> This could be as easy as having labs in population
centres maintain virus detectors
455 -> that monitor what is going on in the micro world.
457.998 -> If we suddenly see certain microorganisms
show up a lot in a short time, we can react quickly
463.2 -> and start counter measures.
465.412 -> Which is the final step: Destroy.
468.319 -> We basically need to build a machine that
is ready to destroy any pandemic threat
472.372 -> before it has a chance to take over.
474.753 -> We can do this with new tools that are being
developed right now, like nanofilters
478.756 -> that pull dangers out of the air we breathe or
specialized UV lamps that just kill any virus
484.099 -> before it has a chance to jump from person
to person.
486.93 -> And of course, we need to get better at getting
new vaccines faster than ever before in history.
492.095 -> If we do these three things, the chances are really
good that we can avoid
495.549 -> a catastrophic pandemic in the future.
498.503 -> Biotechnology, like any exciting and powerful
technology, is neither inherently good or bad.
505.316 -> It has the potential to be both in breathtaking
ways.
509 -> We have the chance to a future where we get
to truly control biology - our biology,
514.475 -> the biology of the plants and animals around us
– and the biology of the microworld.
519.581 -> So let’s use it to create a future where
we triumph over pandemics and diseases for good.
526.461 -> This video was supported by Open Philanthropy.
529.279 -> If you want to help and want to have a high
impact on the world,
531.816 -> check out the biorisk career guide from 80,000 hours,
535.286 -> a nonprofit organisation that helps people find careers
537.89 -> that can tackle some of humanity's greatest problems
in the most efficient way.
542.279 -> We put a link and further reading in the description
and sources.
545.35 -> Aside from biorisk there are more guides to
check out too!
549.477 -> Let us tell you about one of the most embarrassing
moments in kurzgesagt history,
553.425 -> it’s a pretty great story.
554.959 -> A few years ago we posted an image of a fake
evolutionary tree on social media.
559.648 -> Just to post something nice, without thinking
about it.
562.89 -> But we messed with the wrong birbs.
564.67 -> Immediately we got thousands of messages
from you telling us how wrong it was, unscientific,
570.279 -> bad.
571.279 -> We underestimate that you take everything
that we put out into the world seriously and
575.06 -> you set high standards for our research and
fact-checking process.
578.709 -> This hurt.
579.96 -> A lot.
580.718 -> We wanted to be better than that.
582.562 -> So we deleted it and contacted experts and
spent hundreds of hours on research and illustration
587.85 -> and developed a new visualization of the relationships
between species that did not exist before.
593.25 -> A Map of Evolution you can use to figure out
how closely you are related to a Flying Lemur:
598.28 -> Expert approved.
599.65 -> We were extremely proud of the result – and
since we had spent so much time on it,
603.409 -> we turned it into a poster.
604.93 -> And from that a new vision was born:
607.348 -> We wanted to become the best infographic and scienceposter shop in the world.
611 -> Today we’ve designed almost 100 posters
and sold over half a million copies
616.347 -> – every single one made with love, care and lots of
attention to detail.
621 -> All because you guys challenged us.
623.39 -> Thank you so much for that and for supporting
our weird ideas and our sometimes weird Merch.
629.468 -> Because of you we can continue to release
our videos for free for everyone and drop
633.19 -> hundreds of hours into new concepts to spark
curiosity in people all around the world.
638.176 -> Thank you so, so much for being part of our
vision – we literally couldn’t do it without you.
